Esonix 20mg Capsule

✔️ Uses of Esonix 20mg Capsule

Treatment of 

• Erosive Esophagitis
• Gastroesophageal Reflux Disease
• Helicobacter Pylori Infection
• Zollinger-Ellison Syndrome
• Other Forms Of Ulcers
• Acidity
• Heartburn

✔️ How does Esonix 20mg Capsule work?

Esonix 20mg Capsule decreases the acid production in your stomach. It also fastens the healing process for ulcers.

✔️ Side Effects of Esonix 20mg Capsule

• Abdominal Pain
• Fever
• Joint Pain
• Sore Throat
• Loss Of Appetite
• Constipation
• Diarrhea
• Difficulty In Breathing
• Dizziness
• Muscle Pain
• Drowsiness
• Rash
• Back Pain
• Swelling of face, lips, eyelids, tongue, hands and feet
• Irregular heartbeat

✔️ Quick Suggestions:

• Avoid eating late at night or right before bedtime to minimize the risk of acid reflux.
• If you experience watery diarrhea, fever, or stomach pain that does not go away, inform your doctor as these may require medical attention.
• Prolonged use of esomeprazole can lead to weakened bones and deficiencies in minerals like magnesium. It's important to follow your doctor's advice regarding dietary intake of calcium and magnesium or supplementation to maintain mineral balance.
• Avoid foods and drinks that can trigger acid reflux, such as onions, peppermint, chocolate, caffeinated beverages, citrus fruits or juices, tomatoes, and high-fat or spicy foods. Including high-fiber foods, berries, cherries, leafy green vegetables, and black pepper in your meals can provide antioxidants, calcium, and vitamin B12 to help counteract the potential long-term effects of the medication.
• Elevating the head and chest by raising the bedhead or using a single raised block can help prevent stomach acid from flowing back into the esophagus during sleep.
• Avoid alcohol consumption and smoking, as alcohol can increase stomach acid production and nicotine can damage the valve that prevents acid reflux.
• Incorporating fermented dairy products like miso, sauerkraut, and kimchi, which contain probiotics, may help prevent excessive stomach acid production. Cranberry juice can be beneficial in cases of peptic ulcers and H. pylori infection.
• Avoid sitting continuously for long periods. Take regular breaks by engaging in brisk walking or stretching every hour to help manage stomach acid production.
• If you experience decreased urination, edema (swelling due to fluid retention), lower back pain, nausea, fatigue, rash, or fever, consult your doctor promptly as these symptoms could indicate a kidney problem.

✔️ Indication of Esonix 20mg Capsule

Reflux Esophagitis

• Erosive Esophagitis is the swelling of the esophagus, the tube that carries food from your throat to your stomach. It occurs when excess acid produced in the stomach flows back into your esophagus, causing irritation and damage. Esonix 20mg Capsule is used to treat erosive esophagitis.

Gastroesophageal Reflux Disease

• Gastroesophageal Reflux Disease (GERD) is a condition that occurs when stomach acid frequently flows back into your food pipe. The symptoms include heartburn, indigestion, difficulty in swallowing, etc. Esonix 20mg Capsule helps in the treatment of GERD by decreasing stomach acid production.

Helicobacter Pylori Infection

• Helicobacter Pylori infection is a bacterial infection affecting your stomach and intestine caused by Helicobacter pylori. It is a very common infection that may cause ulcers in your stomach and intestine. Esonix 20mg Capsule is used in combination with antibiotics to treat and prevent Helicobacter Pylori infection.

Zollinger-Ellison Syndrome

• Zollinger-Ellison Syndrome is a condition in which tumors form in the pancreas (an organ located behind the stomach) and duodenum (the first part of the small intestine). These tumors produce a hormone called gastrin which in turn causes excessive stomach acid. Esonix 20mg Capsule is used to reduce the excessive amount of acid produced in the stomach due to tumors.

Peptic Ulcer

• Peptic ulcers are sores that are formed in the lining of your stomach and duodenum (the beginning of the small intestine). It occurs when excess acid produced in the stomach damages the protective layer of your stomach and small intestine. Esonix 20mg Capsule is used to treat ulcers of the stomach and small intestine.

✔️ Pharmacology

Esomeprazole is a proton pump inhibitor (PPI) that works by suppressing gastric acid secretion in the stomach. It achieves this by inhibiting the H+/K+ ATPase enzyme, also known as the gastric proton pump, in the gastric parietal cells. This enzyme is responsible for the final step of acid production in the stomach.

Esomeprazole is the S-isomer of omeprazole, another PPI medication. It is considered the more active form of the drug and has a slightly different pharmacokinetic profile compared to omeprazole. Esomeprazole is often used to treat conditions such as gastroesophageal reflux disease (GERD), stomach ulcers, and Zollinger-Ellison syndrome, where there is an overproduction of stomach acid.

By inhibiting acid production, esomeprazole helps reduce symptoms associated with excess stomach acids, such as heartburn, acid reflux, and stomach ulcers. It is commonly available in oral tablets or capsule formulations for oral administration.

✔️ Dosage & Administration of Esonix 20mg Capsule

Esomeprazole tablet or capsule should be swallowed whole and taken one hour before a meal.

Take Esonix 20mg Capsule as advised by your doctor. Swallow Esonix 20mg Capsule with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.

✔️ Interaction

Drug-Drug Interactions: Before taking Esonix 20mg Capsule, it is important to inform your doctor about any other medications you are taking, as they may interact with this drug. Some examples of medications that can interact with Esonix 20mg Capsule include:

1. Antibiotics are used to treat ulcers caused by Helicobacter pylori infection (e.g., amoxicillin, clarithromycin).
2. Medicines used to treat HIV infection (e.g., nelfinavir, atazanavir).
3. Medicines used to prevent blood clots (e.g., clopidogrel, warfarin).
4. Antifungal medicines (e.g., ketoconazole, itraconazole, voriconazole).
5. Medicine used to treat cancer (e.g., erlotinib).
6. Antidepressants used to treat depression (e.g., citalopram, imipramine, clomipramine) or St. John's wort (Hypericum perforatum).
7. Medicines are used to treat anxiety, relax muscles, or epilepsy (e.g., diazepam).
8. Medicine used in epilepsy (e.g., phenytoin).
9. Medicines are used to treat intermittent leg pain caused by insufficient blood supply (e.g., cilostazol).
10. Medicines are used for indigestion and heartburn (e.g., cisapride).
11. Digoxin (a medicine used for heart problems).
12. Methotrexate (a medicine used in high doses to treat cancer).
13. Immunosuppressants for organ transplantation (e.g., tacrolimus).
14. Medicines used for the treatment of tuberculosis (e.g., rifampicin).
15. Medicines that increase magnesium, such as diuretics (e.g., hydrochlorothiazide, chlorthalidone).

Drug-Food Interactions: 

Esonix 20mg Capsule may interact with St. John's wort, which is a plant commonly used as an antidepressant. The intake of St. John's wort may affect the effectiveness of Esonix 20mg Capsule. Therefore, it is advised to avoid taking St. John's wort while using Esonix 20mg Capsules.

Drug-Disease Interactions: 

Esonix 20mg Capsule should not be given to patients with the following conditions:

1. Clostridium difficile-associated diarrhea.
2. Magnesium and vitamin B12 deficiency, as may increase the risk of bone fracture.
3. Atrophic gastritis (inflamed lining of the stomach).
4. Acute interstitial nephritis (inflamed cells of the kidney).

It is important to inform your doctor if you are taking any of these medications to ensure that there are no potential interactions or to adjust the dosage if necessary.

✔️ Overdosage:

If you or someone else accidentally takes more than the prescribed dose of Esonix 20mg Capsule, it is important to seek immediate medical attention. Symptoms of overdose may include reduced physical activity, changes in respiratory rate, tremors, coordination-balance-speech disorders (ataxia), and intermittent fits (clonic convulsions).

✔️ Contraindications

Esomeprazole, the active ingredient in Esonix 20mg Capsule, is contraindicated in patients with known hypersensitivity (allergy) to any component of the formulation or to substituted benzimidazoles. If you have a known hypersensitivity to esomeprazole or any related medications, it is important to avoid taking Esonix 20mg Capsule or any other product containing esomeprazole. Allergic reactions can range from mild symptoms like rash and itching to severe reactions such as difficulty breathing and swelling of the face, lips, tongue, or throat. If you experience any signs of an allergic reaction, seek immediate medical attention. It's crucial to inform your healthcare provider about any known allergies before starting any new medication.

✔️ Pregnancy & Lactation

There are limited data available on the use of esomeprazole (the active ingredient in Esonix 20mg Capsule). However, studies on omeprazole, which is the racemic mixture containing both the S- and R-isomers of esomeprazole, have not demonstrated an increased risk of major congenital malformations or adverse pregnancy outcomes with first-trimester use. Available epidemiologic data on omeprazole use during pregnancy have not shown an increased risk of harm to the fetus.

In animal studies, such as those conducted on rats and rabbits, dose-dependent embryo-lethality was observed with omeprazole doses that were significantly higher than the human equivalent dose of 40 mg based on body surface area. However, animal studies do not always directly translate to human outcomes.

Regarding lactation, omeprazole, which is the precursor to esomeprazole, has been found to be present in human milk based on limited data. The clinical data on the effects of esomeprazole on breastfed infants or milk production are not available. When considering the use of esomeprazole in breastfeeding mothers, it is important to weigh the potential benefits of breastfeeding for the infant's development and health against the mother's clinical need for the medication and any potential adverse effects on the breastfed infant.

If you are pregnant, planning to become pregnant, or breastfeeding, it is crucial to consult your healthcare provider before using Esonix 20mg Capsule or any other medication to assess the potential risks and benefits in your specific situation. Your doctor will consider your individual circumstances and make the best recommendation for your care.

✔️ Precautions & Warnings

• Gastric cancer: Prolonged use of Esonix 20mg Capsule may mask the symptoms of gastric cancer. If you experience severe stomach pain or gastric bleeding (blood in the mucous or stool), it is important to consult your doctor promptly.
• Liver disease: Individuals with liver disease should use Esonix 20mg Capsule with caution, as the drug is metabolized in the liver. Dose adjustments may be necessary.
• Low magnesium level (osteoporosis) and low vitamin B12: Prolonged intake of Esonix 20mg Capsule may lead to deficiencies in magnesium and vitamin B12. Regular monitoring and appropriate supplementation, if necessary, should be considered under medical supervision.
• Pregnancy and breast-feeding: Esonix 20mg Capsule can be used during pregnancy and breastfeeding, but it should be taken only after consulting a doctor. The potential risks and benefits should be carefully evaluated.

✔️ Storage Conditions

Store at a temperature not exceeding 30°C in a dry place. Protect from light and moisture. Keep out of reach of children.